Biomaterials, a trending enabling technology
Biomaterials can be defined as engineered materials tailored to interact with living systems for therapeutic or diagnostic purposes. High versatility, biocompatibility and biodegradability are important features of biomaterials that have attracted a great interest from the scientific community over the years.
Biomaterials are a trending enabling technology in emergent therapeutic modalities and diagnostic procedures. Possibilities can be as varied as biosensing and bioimaging, immunotherapy, controlled drug delivery, regenerative medicine, and tissue engineering not only for organ replacement but also to create 3D disease models and test new therapies. The development of stimuli-intelligent medical devices, theragnostic, or nanorobotics is among the many exciting applications for biomaterials. Stemmatters extensive experience in the field has led to the establishment of a versatile biomaterial-based product development platform (mimsys®), that will help push forward the next generation of medical devices and investigational medicinal products.
The SENTINEL project aims to develop an implantable biosensor for early tumor surveillance. The biosensor is aimed to be implanted under the patient skin for optical evaluation of the disease state, at home, in less than a minute. It is composed of a biomaterial chassis - a key element for the success of the SENTINEL project, which will determine the implantation procedure, biocompatibility, and the expected lifetime of the device.
Stemmatters has developed a library of biomaterials chemically to address the challenges of the SENTINEL project. The injectability of the newly synthesized chemical entities allows for minimally invasive implantation while guaranteeing a stable 3D structure with controlled porosity to allow plasmonic particles to provide label-free detection of biomarkers of interest. The versatility of the new biomaterial library will allow simple and straightforward finetuning of important properties such as degradation rate or surface chemistry, to assure functionality, safety, and compliance with medical regulations.
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